The cinematic show has placed centre and front as our antagonist in Diablo IV. Her source story is ideal for a individual that is grey. Contrary to the Prime Evils of others, and also Diablo, Mephisto, Baal, waging an eternal war was not of any attention to Lilith.
Rather, her activities caused the discovery of common ground between two allegedly incompatible sides, the creation of Sanctuary, humanity, and the nephalem. Lilith in this way may occupy a brand new place within the Diablo series' ethical spectrum. The Prime Evils might not form a part of her alliances, nor may the Angels.
Therefore, what would make her offender to become an antagonist? That would likely go back to her original urge to prevent the Eternal Conflict, and to do so, she could consider it essential to create again a different world, a new Sanctuary, and another offspring such as the first nephalem, stronger than anything before. This could allow Lilith to potentially prevent the Eternal Conflict by destroying everything, and possibly that's the problem players must contend with. Would Sanctuary also require the sacrifice of itself humanity and all inside?
Maybe we will not see much of Lilith. A different way to prepare for this grand devastation would be for Lilith to perform puppet master to weaken the Prime Evils, and sending the nephalem controlled by this game's players would help accomplish this goal.
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